Reece Lyne's late try made the difference as Wakefield Trinity Wildcats stunned defending First Utility Super League champions Wigan to record their first win over the Warriors since 2009.
A youthful Wigan side without the likes of Sean O'Loughlin, John Bateman and Matty Bowen played their part in an excellent match but ultimately fell to a 36-28 defeat.
Chris Bridge's 16-point haul helped Warrington earn their seventh successive win as they beat Salford 36-20 at the Halliwell Jones Stadium.
Bridge contributed a try and added six goals as the Wolves recovered from falling behind to an early Junior Sau try to make it five consecutive victories against the Red Devils, with loose forward Ben Harrison particularly impressive.
Warrington ran in six tries to Salford's four but it was not a five star performance from Tony Smith's men.
Leeds stand-off Danny McGuire bagged a brace of tries as the Rhinos fought off a valiant Widnes charge to take the points at the Select Security Stadium.
McGuire was at his creative, poaching best for the Rhinos and his two efforts either side of half-time proved to be the difference between the teams.
The Vikings had no less than seven players missing from their starting line-up from the side that faced Hull and Wigan last week and a 38-28 Leeds win would not have been a surprise.
Veteran Paul Wellens once more demonstrated his immense value to St Helens by guiding them to a comprehensive 38-16 win over top-four rivals Castleford at Langtree Park.
The 34-year-old former Great Britain international, who registered the 1,000th point of his career in Saints' 30-28 win at Castleford earlier this year, scored two of his side's seven tries as they completed the double over the Challenge Cup semi-finalists.
Wellens proved a magnificent replacement for injured full-back Jonny Lomax as Saints bounced back from the humiliation of their 42-0 hammering by Catalan Dragons to move back to the top of the standings.