Manu Tuilagi and Marland Yarde have been restored to England's squad ahead of Sunday's RBS 6 Nations clash with Wales, the Rugby Football Union has announced.
Tuilagi and Yarde have recovered from the respective pectoral and hip injuries that have prevented them from participating in the championship to date.
The three-quarter duo will arrive at England's training camp in Bagshot on Monday night, but neither player is likely to be involved against Wales.
Head coach Stuart Lancaster insists Tuilagi and Yarde would have to produce something spectacular in training before the team is announced on Friday to play in the penultimate match of the Six Nations.
"They'd have to go some in the next couple of days, it's fair to say," Lancaster said.
"It's a big ask for Manu to come back having had such a long period out.
"He hasn't had any time with us in camp whatsoever, so Tuesday will be the first training session he's done since the Wales game last year."
Since losing to France on the opening weekend England have delivered impressive wins against Scotland and Ireland to propel them back into title contention.
Luther Burrell has excelled in Tuilagi's traditional position of outside centre, while Jack Nowell's form warrants his ongoing selection on the right wing ahead of Yarde.
"You can't say how this match against Wales will go. Things could change, we'll just have to wait and see," Lancaster said.
Wales will be making their final visit to Twickenham before the rivals meet at the same venue in the pool stages of the 2015 World Cup, and Lancaster added: "Any games against sides that will be in your World Cup pool will always have significance, but this is a game in isolation.
"You reflect back on the previous games you've played against them and you might project and look forward, but it will be the best team on the day that will win.
"Every game is important. We understand the size of the game. It's a big game in the context of this championship.
"If you have ambitions to win the Six Nations, and we set those out at the start, then we have to win this game. We're well aware of that."