Duke Dumont has scored his second number one single with I Got U going straight to the top of the charts.
The house anthem features Jax Jones and samples Whitney Houston classic My Love Is Your Love.
The London-based DJ and producer's first chart topper, Need U (100%), kept controversial number one contender Ding Dong The Witch Is Dead off the top spot last April following the death of former Prime Minister Baroness Thatcher.
According to the Official Charts Company, Route 94's My Love FT Jess Glynne holds firm at number two, while John Legend's ballad, All Of Me, climbs three places to number three.
This week's top five is completed by Pharrell Williams' Happy, down one place to four, and last week's chart-topper, Tsunami (Jump) by Dvbbs, Borgeous and Tinie Tempah at number five.
Little Mix claim this week's second highest new entry - and their fifth top 10 single - with Word Up at number six. The girl group's cover of Cameo's 1986 hit is the official single of Sport Relief 2014.
English rapper Example is new in at 13 with Kids Again, a track taken from his forthcoming fifth studio album, Live Life Living.
Meanwhile The Human League's 1981 number one Don't You Want Me topped the Official Scottish Singles Chart thanks to a social media campaign by fans of Aberdeen Football Club.
The track is popular with the team's supporters, who change the lyrics of the chorus to "Peter Pawlett, baby" after their 22-year-old midfielder.
"I'm absolutely astounded to see what's happened this week," Pawlett told OfficialCharts.com.
"I massively appreciate the way the Aberdeen fans have got on board and bought the record."
The track is number 19 in the UK charts.
In the albums chart George Michael's Symphonica beat Kylie Minogue's Kiss Me Once to the top spot by more than 20,000 copies, earning him his seventh UK number one album.
"Thank you so much," the former Wham! star told OfficialCharts.com.
"Symphonica is at this moment sitting at number one in the UK, and it's so nice to be able to savour this wonderful moment. I am a lucky man."
It is his first new album in nearly 10 years and was recorded during the singer's 2011/12 world tour.
Pharrell Williams' G I R L remains static at number three, Paloma Faith's A Perfect Contradiction is down two to number four, and last week's chart-toppers Elbow complete the top five with The Take Off And Landing Of Everything.