Entry was forced and raiders stole items including an eight foot grandfather clock and 6ft by 4ft cabinet along with Chinese-style pottery and antique jewellery.
The burglary in hazeley Road was between 8.30pm on Thursday, May 8 and 10.30am on Friday, May 9.
PC Jasmin Connolly from Winchester police station said: “This burglary has been devastating for the family as many precious family belongings have been stolen including very large pieces of furniture.
“The offenders must have used a van to remove the items and there are likely to have been at least two offenders.”
Anyone with information should contact PC Connolly at Winchester police station by calling 101. Alternatively call Crimestoppers anonymously on 0800 555 111.